Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors
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چکیده
منابع مشابه
Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors
A small set of nojirimycin- and pyrrolidine-based iminosugar derivatives has been synthesized and evaluated as potential inhibitors of porcine and insect trehalases. Compounds 12, 13 and 20 proved to be active against both insect and porcine trehalases with selectivity towards the insect glycosidase, while compounds 10, 14 and 16 behaved as inhibitors only of insect trehalase. Despite the fact ...
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ژورنال
عنوان ژورنال: Beilstein Journal of Organic Chemistry
سال: 2012
ISSN: 1860-5397
DOI: 10.3762/bjoc.8.58